ANTI-CONNEXIN 43 ANTIBODY, MOUSE MONOCL

Code: SAB4200730-25UL D2-231

Biochem/physiol Actions

Connexin 43 (Cx43) function is controlled by phosphorylation, SUMOylation and ubiquitination. The C-terminal tail of Cx43 modulates cytoskeletal dynam...


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Biochem/physiol Actions

Connexin 43 (Cx43) function is controlled by phosphorylation, SUMOylation and ubiquitination. The C-terminal tail of Cx43 modulates cytoskeletal dynamics and cell migration properties. Mutation in Cx43 leads to dysfunction of channel regulation domain and is associated with pathogenesis of hypoplastic left heart syndrome (HLHS). Cx43 dysregulation in testis contributes to infertility and testicular tumor. A gene mutation in the Cx43 results in abnormal development of eyes and teeth in oculodentodigital dysplasia (ODDD) , craniometaphyseal dysplasia and sudden infant death syndrome. Mutations in the GJA1 results in abnormal facial and skull development in hallermann-streiff syndrome (HSS). Missense mutations in GJA1 gene is also implicated in skin disorder called the, erythrokeratodermia variabilis et progressiva (EKVP)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Connexin 43 (Cx43) is also known as gap junction alpha-1 protein (GJA1). It is mapped to human chromosome 6q22.31. Cx43 is membrane protein with four transmembrane spanning regions, which comprise the gap junction channel. The loop connecting the transmembrane regions play a key role in channel docking. The N- and C-terminal amino acids are exposed to cytoplasm.

Immunogen

synthetic peptide from the C-terminal region of Connexin 43 protein, conjugated to KLH

Physical form

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

antibody formculture supernatant
antibody product typeprimary antibodies
biological sourcemouse
cloneCXN-6, monoclonal
concentration~1.0 mg/mL
formbuffered aqueous solution
Gene Informationbovine ... Gja1(281193)cat ... Gja1(101100211)chicken ... Gja1(395278)human ... GJA1(2697)mouse ... Gja1(14609)rat ... Gja1(24392)
isotypeIgM
packagingantibody small pack of 25 µL
Quality Level200
shipped indry ice
species reactivitybovine, rat, porcine, human, chicken, feline, mouse
storage temp.−20°C
technique(s)immunofluorescence: 1:500-1:1,000 using mouse myoblast C2C12 cell line, immunoblotting: 1:5,000-1:7,500 using mouse myoblast C2C12 cell line extract, immunohistochemistry: 1:200-1:500 using heat-retrieved formalin-fixed, paraffin-embedded mouse heart sections
UniProt accession no.P17302
This product has met the following criteria to qualify for the following awards:



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